<rt id="ki6es"><center id="ki6es"></center></rt>
<rt id="ki6es"><optgroup id="ki6es"></optgroup></rt>
<acronym id="ki6es"></acronym>
波兰科学院院士Tomasz Dietl教授谈磁性半导体
A Fast and Universal RFID Tag Anti-Collision Algorithm for the Internet o...
Self-Powered Flexible Blood Oxygen Monitoring System Based on a Triboelec...
Performance Improvement of GaN Based Laser Diode Using Pd/Ni/Au Metalliza...
Enhancement of Heat Dissipation in Ultraviolet Light-Emitting Diodes by a...
Heterointerface-Driven Band Alignment Engineering and its Impact on Macro...
Highly Polarized Photoelectrical Response in vdW ZrS3 Nanoribbons
Strain compensated robust semiconductor saturable absorber mirror for fib...

Label-Free Exosome Detection Based on a Low-Cost Plasmonic Biosensor Array Integrated with Microfluidics


Authors: Lv, XQ; Geng, ZX; Su, Y; Fan, ZY; Wang, SC; Fang, WH; Chen, HD


Volume: 35 Issue: 30 Pages: 9816-9824 Published: JUL 30 2019 Language: English Document type: Article

DOI: 10.1021/acs.langmuir.9b01237


Localized surface plasmon resonance-based plasmonic biosensors are interesting candidates for the design of portable optical biosensor platforms owing to their integration, miniaturization, multiparameter, real-time, and label-free detection characteristics. Plasmonic biosensor arrays that have been combined with microfluidics have been developed herein to detect exosomes label-free. Gold nano-ellipsoid arrays were fabricated with low-cost anodic aluminum oxide thin films that act as shadow masks for evaporation of Au. The nano-ellipsoid arrays were integrated with a microfluidic chip to achieve multiparameter detection. The anti-CD63 antibody that is specific to the exosome transmembrane protein CD63 is modified on the surface of the nano-ellipsoids. Exosome samples were injected into the biosensor platform at different concentrations and detected successfully. The detection limit was 1 ng/mL. The proposed plasmonic biosensor array can be universally applicable for the detection of other biomarkers by simply changing the antibody on the surface of the Au nano-ellipsoids. Moreover, this biosensor platform is envisaged to be potentially useful in the development of low-cost plasmonic-based biosensors for biomarker detection and for the investigation of exosomes for noninvasive disease diagnoses.

Full Text: https://pubs.acs.org/doi/10.1021/acs.langmuir.9b01237


北京市海淀区清华东路甲35号 北京912信箱 (100083)





版权所有 ? 中国科学院半导体研究所

备案号:京ICP备05085259号 京公网安备110402500052 中国科学院半导体所声明

<rt id="ki6es"><center id="ki6es"></center></rt>
<rt id="ki6es"><optgroup id="ki6es"></optgroup></rt>
<acronym id="ki6es"></acronym>